| 标题 |
  In vivo CAR T cell generation to treat cancer and autoimmune disease 相关领域
嵌合抗原受体
细胞毒性T细胞
抗原
生物
免疫学
T细胞
CD8型
细胞生物学
癌症研究
免疫系统
遗传学
体外
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| 网址 | |
| DOI |
提醒：求助人提供的doi与AI识别不一致
10.1038/s41590-024-02034-1
Doi
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| 其它 | Chimeric antigen receptor (CAR) T cell therapies have transformed treatment of B cell malignancies. However, their broader application is limited by complex manufacturing processes and the necessity for lymphodepleting chemotherapy, restricting patient accessibility. We present an in vivo engineering strategy using targeted lipid nanoparticles (tLNPs) for messenger RNA delivery to specific T cell subsets. These tLNPs reprogrammed CD8+ T cells in both healthy donor and autoimmune patient samples, and in vivo dosing resulted in tumor control in humanized mice and B cell depletion in cynomolgus monkeys. In cynomolgus monkeys, the reconstituted B cells after depletion were predominantly naïve, suggesting an immune system reset. By eliminating the requirements for complex ex vivo manufacturing, this tLNP platform holds the potential to make CAR T cell therapies more accessible and applicable across additional clinical indications. |
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