| 标题 |
 Large-scale proteomics identifies MMP-7 as a sentinel of epithelial injury and of biliary atresia 相关领域
胆道闭锁
蛋白质组学
医学
生物
计算生物学
病理
内科学
生物化学
基因
移植
肝移植
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| 其它 |
Bile duct injury marker to the rescue Biliary atresia is a poorly understood pediatric disease, which is associated with progressive bile duct obstruction and liver injury in young infants. Early diagnosis of this condition is crucial for restoring bile flow and protecting the liver from irreversible damage, but the disease can be difficult to distinguish from more common causes of cholestasis. By performing proteomics on large sets of patient samples, Lertudomphonwanit et al. identified the serum concentration of a protein called matrix metalloproteinase-7 as a promising diagnostic marker of this disease, especially when used together with γ-glutamyltranspeptidase, a less specific marker of cholestasis. The authors also investigated the mechanistic role of matrix metalloproteinase-7 in bile ducts, supporting the biological relevance of this marker. |
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