| 标题 |
 Phage arabinosyl-hydroxy-cytosine DNA modifications result in distinct evasion and sensitivity responses to phage defense systems 相关领域
生物
DNA
噬菌体
清脆的
限制性酶
核糖核酸
遗传学
基因
分子生物学
大肠杆菌
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| 网址 | |
| DOI | |
| 其它 |
Marina Mahler 1, Liang Cui 2, Leah M Smith 3, Katharina G Wandera 4, Oliver Dietrich 4, David Mayo-Muñoz 5, Seetharamsing Balamkundu 6, Megan En Lee 6, Hong Ye 6, Chuan-Fa Liu 6, Junzhou Wu 7, Juby Mathew 8, Jeremy Dubrulle 4, Lucia M Malone 4, Simon A Jackson 5, Antony J Fairbanks 9, Affiliations Expand PMID: 40578341 DOI: 10.1016/j.chom.2025.06.005 Abstract Bacteria encode diverse anti-phage systems, such as CRISPR-Cas and restriction modification (RM), which limit infection by targeting phage DNA. We identified a DNA modification in phages, i.e., 5-arabinosyl-hydroxy-cytosine (5ara-hC), which adds arabinose to cytosines via a hydroxy linkage and protects phage from DNA targeting. The hydroxy linkage was common among arabinoslyated phages, with some arabinosylated phages encoding arabinose-5ara-hC transferases (Aat) that add a second or third arabinose to DNA. Keywords: CRISPR-Cas; DNA modification; anti-phage systems; phage defenses; phages; restriction-modification. |
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