| 标题 |
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  Murine vascular organoids are responsive and adaptable 3D systems with cellular heterogeneity and dynamic plasticity 相关领域
类有机物
胚胎干细胞
体外
生物
可塑性
细胞生物学
干细胞
神经科学
免疫组织化学
血管平滑肌
内皮干细胞
成体干细胞
表型
球体
巨噬细胞
转录组
移植
血管内皮生长因子
翻译（生物学）
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Blood vascular organoids (BVOs) have emerged as powerful tools for interrogating endothelial heterogeneity, function, and organ- specific cues during development, homeostasis, and disease. Here, we describe the stepwise generation and characterization of murine BVOs from different embryonic stem cells and introduce a fluorescent tracer system to follow their formation and maturation, visualizing functional and perfused vessels after trans plantations into mice. Single- cell RNA sequencing, FACS, and whole- mount immunohistochemistry revealed a heterogeneous and dynamic trajectory of multiple endothelial, mesenchymal, and macrophage clusters in mBVOs at growth spike and full maturation. Endothelial cells inferred high plasticity toward arterial, venous, capillary, and tip/stalk cells and a neural- like identity at full maturation state. |
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(2025-6-4)
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