| 标题 |
 Interstitial fluid drainage is impaired in ischemic stroke and Alzheimer's disease mouse models |
| 网址 | |
| DOI | |
| 其它 | The interstitial fluid (ISF) drainage pathway has been hypothesized to underlie the clearance of solutes and metabolites from the brain. Previous work has implicated the perivascular spaces along arteries as the likely route for ISF clearance; however, it has never been demonstrated directly. The accumulation of amyloid beta (A beta) peptides in brain parenchyma is one of the pathological hallmarks of Alzheimer disease (AD), and it is likely related to an imbalance between production and clearance of the peptide. A beta drainage along perivascular spaces has been postulated to be one of the mechanisms that mediate the peptide clearance from the brain. We therefore devised a novel method to visualize solute clearance in real time in the living mouse brain using laser guided bolus dye injections and multiphoton imaging. |
| 求助人 | |
| 下载 | 该求助完结已超 24 小时，文件已从服务器自动删除，无法下载。 |
PDF的下载单位、IP信息已删除
(2025-6-4)
cdercder
无极微光
Nole
XX
OK
leery
arniu2008
8R60d8
Kao
学术文献互助
AireenBeryl531
囧囧
fancy
xing_xing
馨馨的科科
周芝鹤
huang
修仙中
aajhajkahna
sagitar
皖公网安备34019202002308
