| 标题 |
 Cancer-associated fibroblasts drive lung adenocarcinoma progression via THBS2-mediated epithelial-mesenchymal transition 相关领域
生物
上皮-间质转换
体内
癌症研究
转录组
腺癌
过渡（遗传学）
癌症
体外
肺
癌变
肺癌
免疫组织化学
表型
肺腺癌
人肺
病理
肿瘤微环境
肿瘤进展
动力学（音乐）
核糖核酸
细胞外基质
多路复用
信使核糖核酸
肿瘤发生
细胞生物学
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| 其它 | The role of cancer-associated fibroblasts (CAFs) in the initiation and invasion phases of human lung adenocarcinoma (LUAD) development is not fully understood. In this study, we utilized single-cell RNA sequencing, spatial transcriptomics, and a combination of in vivo and in vitro models to decode the dynamics of tumor-stroma interactions during human LUAD progression, focusing primarily on adenocarcinoma in situ (AIS), minimally invasive adenocarcinoma (MIA), and invasive adenocarcinoma (IAC). We identified a matrix CAF (mCAF) subtype characterized by high THBS2 expression, which was closely associated with poor clinical outcomes, tumor recurrence, and the invasive dynamics of LUAD. Spatial transcriptomics and multiplex immunohistochemistry analysis revealed that this CAF subpopulation was closely associated with tumor cells, with clear spatial colocalization. |
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(2025-6-4)
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