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 The landscape of small-molecule prodrugs 相关领域
前药
化学信息学
小分子
药理学
组合化学
生化工程
计算生物学
纳米技术
化学
生物
工程类
计算化学
材料科学
生物化学
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| 其它 |
Nature Reviews Drug Discovery volumem 23, pages 365–380 (2024) Abstract:Prodrugs are derivatives with superior properties compared with the parent active pharmaceutical ingredient (API), which undergo biotransformation after administration to generate the API in situ. Although sharing this general characteristic, prodrugs encompass a wide range of different chemical structures, therapeutic indications and properties. Here we provide the first holistic analysis of the current landscape of approved prodrugs using cheminformatics and data science approaches to reveal trends in prodrug development. We highlight rationales that underlie prodrug design, their indications, mechanisms of API release, the chemistry of promoieties added to APIs to form prodrugs and the market impact of prodrugs. On the basis of this analysis, we discuss strengths and limitations of current prodrug approaches and suggest areas for future development. |
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