标题 |
Protective role of Lactobacillus plantarum A7 against irinotecan-induced genotoxicity
植物乳杆菌A7对伊立替康遗传毒性的保护作用
相关领域
伊立替康
遗传毒性
彗星试验
植物乳杆菌
DNA损伤
药理学
化学
结直肠癌
医学
生物
癌症
毒性
DNA
生物化学
内科学
有机化学
乳酸
细菌
遗传学
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其它 | 摘要:.OBJECTIVE(#br)Irinotecan is a botanical derivative and an anti-cancer drug with cytotoxic and genotoxic effects. The present study evaluated the effect of Lactobacillus plantarum A7 on the genotoxic activity of irinotecan in a hepatocellular carcinoma cell line (HepG2) by comet assay.(#br)MATERIALS AND METHODS(#br)HepG2 were incubated with irinotecan (100 µM), heat-killed cells (0.025 µg/ml) + irinotecan (100 µM), and cell-free supernatants (0.5 and 1 µg/ml) of L. plantarum A7 + irinotecan (100 µM). Phosphate buffered saline (PBS) was used as negative control. |
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