| 标题 |
 Healthy dietary patterns, genetic risk, and gastrointestinal cancer incident risk: a large-scale prospective cohort study 健康饮食模式、遗传风险和胃肠癌发病风险：一项大规模前瞻性队列研究
相关领域
医学
前瞻性队列研究
破折号
混淆
低风险
饮食与癌症
队列
内科学
比例危险模型
队列研究
人口学
置信区间
计算机科学
操作系统
社会学
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| 网址 | |
| DOI | |
| 其它 |
Abstract Background: Dietary patterns have been associated with several cancers, especially gastrointestinal cancer (GIC). However, whether a healthy dietary pattern could modify the risk of GIC among people with different genetic backgrounds is not clear. Objective: The objective of the study was to investigate how dietary patterns and genetic susceptibility contribute to the risk of GIC independently and jointly. Methods: This large-scale prospective cohort study included 105,463 participants in UK Biobank who were aged 40-72 y and cancer-free at baseline. Dietary intake (Oxford WebQ) was used to calculate dietary pattern scores including dietary approach to stop hypertension (DASH) score and healthful plant-based diet index (hPDI). Genetic risk was quantified by a polygenic risk score (PRS) comprising 129 known GIC-associated loci. Cox proportional hazards regression was performed to estimate the associations of dietary patterns and PRS with GIC incidence after |
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