柔红霉素
阿霉素
部分
化学
衍生工具(金融)
戒指(化学)
立体化学
有机化学
化疗
医学
内科学
金融经济学
经济
作者
J. Kuszmann,G. Medgyes,P. Dvortsak,K. Tory
出处
期刊:Drug Research
[Georg Thieme Verlag KG]
日期:1986-05-01
卷期号:36 (5): 786-9
摘要
This paper describes the synthesis of daunorubicin (daunomycin) analogs, differing from the natural antibiotics in the ring size of the sugar moiety (furanosides instead of pyranosides). Both, the 5-O-methyl derivative 7 as well as the daunosaminofuranoside 16 were less active cytostatics than doxorubicin (adriamycin), but 16 was also much less toxic, consequently its therapeutic index is more favourable.
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