质粒
DNA超螺旋
微生物学
DNA旋转酶
抗菌活性
细菌
根癌农杆菌
生物
化学
大肠杆菌
DNA
转化(遗传学)
生物化学
DNA复制
基因
遗传学
作者
Joséph Molnár,S. Földeák,Mitsuru Nakamura,Holly L. Rausch,K. Domonkos,Márton Szabó
出处
期刊:PubMed
日期:1992-01-01
卷期号:30: 24-31
被引量:13
摘要
The antiplasmid activity of tricyclic compounds, e.g. phenothiazines, dibenzoazepines, dibenzocykloheptene derivatives and some stereoisomers, was shown on E. coli in vitro. Some ring-substituted phenothiazine and cannabis derivatives had only an antibacterial effect. Promethazine, a selected phenothiazine, cured antibiotic resistance and lactose fermentation of E.coli, tumour inducing ability of Agrobacterium tumefaciens and nodule formation of Rhizobium meliloti. Plasmids of different E.coli strains were eliminated with varying frequency. The antiplasmid activity of the compounds can be due to the increased membrane permeability. Inhibition of DNA gyrase and complex formation with the supercoiled form of plasmid DNA can lead to the cessation of plasmid replication in the bacterial cells. In addition, in vivo plasmid curing was demonstrated at a low frequency.
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