癌症治疗
光动力疗法
癌症
材料科学
肿瘤缺氧
癌症研究
纳米技术
放射治疗
医学
化学
内科学
有机化学
作者
Chuanchuan He,Shasha Zhang,Xiaoguang Liu,Jianyu Wang,Yimin Huang,Anxin Zhang,Xiaojuan Zhang
出处
期刊:Nanotechnology
[IOP Publishing]
日期:2023-08-24
卷期号:34 (48): 482002-482002
被引量:19
标识
DOI:10.1088/1361-6528/acf381
摘要
Abstract Metal peroxide-based nanomedicines have emerged as promising theranostic agents for cancer due to their multifunctional properties, including the generation of bioactive small molecules such as metal ions, H 2 O 2 , O 2 , and OH – . Among these metal peroxides, calcium peroxide (CaO 2 ) nanomedicines have attracted significant attention due to their facile synthesis and good biocompatibility. CaO 2 nanoparticles have been explored for cancer treatment through three main mechanisms: (1) the release of O 2 , which helps alleviate tumor hypoxia and enhances oxygen-dependent therapies such as chemotherapy, photodynamic therapy, and immunotherapy; (2) the generation of H 2 O 2 , a precursor for ·OH generation, which enables cancer chemodynamic therapy; and (3) the release of Ca 2+ ions, which induce calcium overload and promote cell apoptosis (called ion-interference therapy). This review provides a comprehensive summary of recent examples of CaO 2 nanoparticle-based cancer therapeutic strategies, as well as discusses the challenges and future directions in the development of CaO 2 nanomedicines for cancer treatment.
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