水泡性口炎病毒
先天免疫系统
内质网
生物
干扰素
病毒学
免疫
免疫系统
模式识别受体
细胞生物学
获得性免疫系统
病毒
免疫学
作者
Tao-tao Shi,Yaping Huang,Ying Li,Xianhua Dai,Yaohui He,Julia Ding,Ting Ran,Yang Shi,Quan Yuan,W Li,Wen Liu
出处
期刊:Science Advances
[American Association for the Advancement of Science (AAAS)]
日期:2023-09-01
卷期号:9 (35)
被引量:1
标识
DOI:10.1126/sciadv.adg7053
摘要
Pattern recognition receptor–mediated innate immunity is critical for host defense against viruses. A growing number of coding and noncoding genes are found to encode microproteins. However, the landscape and functions of microproteins in responsive to virus infection remain uncharacterized. Here, we systematically identified microproteins that are responsive to vesicular stomatitis virus infection. A conserved and endoplasmic reticulum–localized membrane microprotein, MAVI1 (microprotein in antiviral immunity 1), was found to interact with mitochondrion-localized MAVS protein and inhibit MAVS aggregation and type I interferon signaling activation. The importance of MAVI1 was highlighted that viral infection was attenuated and survival rate was increased in Mavi1- knockout mice. A peptide inhibitor targeting the interaction between MAVI1 and MAVS activated the type I interferon signaling to defend viral infection. Our findings uncovered that microproteins play critical roles in regulating antiviral innate immune responses, and targeting microproteins might represent a therapeutic avenue for treating viral infection.
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