瑞戈非尼
医学
入射(几何)
结直肠癌
随机对照试验
内科学
血管内皮生长因子
肿瘤科
皮肤病科
胃肠病学
血管内皮生长因子受体
癌症
光学
物理
作者
Wen-Kuan Huang,Hung‐Chih Hsu,Tsung‐Ming Yang,Chun‐Wei Lu,Yi-Ru Pan,Chieh‐Shan Wu,Wen‐Hung Chung,Shuen‐Iu Hung,Chun‐Nan Yeh
标识
DOI:10.1016/j.ejca.2023.113286
摘要
To the editor: Hand-foot skin reaction (HFSR), characterized by skin abnormalities on palmoplantar surfaces, has an overall incidence of about 35% upon vascular endothelial growth factor receptor-tyrosine kinase inhibitors (VEGFR-TKIs) treatment.1 Zinc, which plays a role in maintaining skin health, may be implicated in the pathogenesis of HFSR.2 Zinc deficiency has been shown to associate with dermatological toxicities of epidermal growth factor receptor (EGFR)-TKI.3, 4 Regorafenib, an oral multi-kinase inhibitor targeting VEGFR 1–3, PDGFR, cKIT, BRAF, and RET1, is approved for the treatment of metastatic colorectal cancer (mCRC) but commonly causes HFSR.5 This phase II randomized trial aimed to investigate whether zinc supplementation can reduce the severity of HFSR induced by regorafenib within the first 8 weeks of treatment (NCT03898102).
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