转录组
生物
计算生物学
仿形(计算机编程)
基因表达谱
外周T细胞淋巴瘤
遗传学
基因
基因表达
T细胞
计算机科学
免疫系统
操作系统
作者
Yan‐Jiun Huang,Yuran Qiu,Qunling Zhang,Minghao Cai,Huilin Yu,Jianming Zhang,Lu Jiang,Mengmeng Ji,Pengpeng Xu,Li Wang,Shu Cheng,Weili Zhao
标识
DOI:10.1016/j.xcrm.2024.101416
摘要
Peripheral T cell lymphoma (PTCL) is a heterogeneous group of non-Hodgkin’s lymphomas varying in clinical, phenotypic, and genetic features. The molecular pathogenesis and the role of the tumor microenvironment in PTCL are poorly understood, with limited biomarkers available for genetic subtyping and targeted therapies. Through an integrated genomic and transcriptomic study of 221 PTCL patients, we delineate the genetic landscape of PTCL, enabling molecular and microenvironment classification. According to the mutational status of RHOA, TET2, histone-modifying, and immune-related genes, PTCL is divided into 4 molecular subtypes with discrete patterns of gene expression, biological aberrations, and vulnerabilities to targeted agents. We also perform an unsupervised clustering on the microenvironment transcriptional signatures and categorize PTCL into 4 lymphoma microenvironment subtypes based on characteristic activation of oncogenic pathways and composition of immune communities. Our findings highlight the potential clinical rationale of future precision medicine strategies that target both molecular and microenvironment alterations in PTCL.
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