区域选择性
烯丙基重排
化学
氨基酸
溶剂
组合化学
有机化学
催化作用
生物化学
作者
Sasa Wang,Shiqiu Peng,Haiying Zhao,Zhijian Liang,Xinliang Lu,Quan Du,Yifan Wang,Bojun Wei,Qin Huang,Haibo Tan
标识
DOI:10.1021/acs.joc.3c02648
摘要
Allylic azlactones are greatly significant in terms of potential bioactivities and synthetic applications. Owing to the burgeoning interest of the pharmaceutical industry in α-amino acid derivatives, discovering strategies for the synthesis of allylic azlactones is important. Herein, we establish a transition-metal-free regioselectivity switch of α-amino acid-derived esters and MBH carbonates, which exhibits broad reaction scope and good reaction yields. Control reactions indicate that both base and solvent are important for regioselectivity.
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