Novel pyrazoline linked acyl thiourea pharmacophores as antimicrobial, urease, amylase and α-glucosidase inhibitors: design, synthesis, SAR and molecular docking studies

IC 50 values of the new synthesized pyrazoline-acyl thioureas revealed 5b and 5g as potent urease inhibitors. Whilst compound 5b is a potent α-glucosidase inhibitor, compound 5f is a potent amylase inhibitor, compound 5b is a potent antioxidant.