Design, synthesis and evaluation of antibacterial activity and mechanism of novel 1‐H‐indole‐3‐pyrazolamide derivatives

This study presents a promising 1-H-indole-3-pyrazole-mercaptoacetamide compound as a novel antibacterial approach. Compound 7 manifests inhibitory actions on Xoo growth by disrupting bacterial flagella assembly, biotin synthesis, the two-component system and the type VI secretion system, showcasing substantial potential for novel antibacterial agent development. © 2025 Society of Chemical Industry.