Periodontitis and Systemic Inflammatory Multimorbidity: Narrative Review of Literature

A BSTRACT An increasing number of systemic inflammatory diseases, such as diabetes mellitus, rheumatoid arthritis (RA), cardiovascular disease, and respiratory disorders, have been linked to periodontitis, a chronic inflammatory condition of the gums. This review delves into the complex connections between systemic inflammatory multimorbidity and periodontitis, emphasizing how these illnesses are exacerbated by chronic inflammation and sharing similar pathophysiological pathways. Common inflammatory pathways that involve periodontal pathogens, like Porphyromonas gingivalis , and important cytokines, like TNF-α, IL-1β, and IL-6, drive the bidirectional link between periodontitis and systemic illnesses. These elements play a part in the systemic spread of inflammation, which has a negative impact on distant organs and tissues. Since treating periodontitis may enhance general health outcomes and lessen the burden of systemic disorders, the review highlights the necessity of an integrated healthcare approach that takes dental and systemic health into account. Healthcare professionals can significantly lessen the effects of systemic inflammatory multimorbidity by treating periodontitis with efficient dental treatment and patient education, thereby improving patient well-being and quality of life.