Thiourea Derivatives in Agrochemical Discovery and Development

Thiourea, represented by the chemical formula (R1R2N)(R3R4N)C═S, is a significant organic sulfur compound characterized by the presence of a sulfur atom and two amino groups. Meanwhile, thiourea and isothiourea are reciprocal isomers. This structure facilitates the formation of a biologically active moiety, which is interconnected through double bonds between the sulfur atom and the nitrogen atoms. As a potent component in pesticide formulations, thiourea demonstrates efficacy in safeguarding crops against a variety of diseases by inhibiting the growth and reproduction of pathogens. This review aims to provide a comprehensive summary of thiourea derivatives exhibiting fungicidal, insecticidal, antiviral, herbicidal, and plant growth regulatory properties, with the objective of offering new perspectives for identifying innovative thiourea-based pesticides and elucidating their mechanisms of action.