Accuracy of Raman spectroscopy in discriminating normal brain tissue from brain tumor: A systematic review and meta-analysis

Raman spectroscopy has a potential to serve as a tool for differentiation of brain tumor from normal brain tissue. Not only could it be helpful in distinguishing malignant lesion from benign with high sensitivity and specificity, but also indicate type of tumor. There is a need for more studies examining the accuracy of spectroscopy in differentiating brain tumors from healthy tissues, especially in vivo and in differentiation of brain tumor subtypes.