硒蛋白
神经退行性变
硒蛋白P
神经科学
功能(生物学)
函数增益
脑功能
生物
人类健康
医学
疾病
氧化应激
细胞生物学
病理
生物化学
环境卫生
突变
谷胱甘肽过氧化物酶
过氧化氢酶
基因
作者
Jessica Nicholson,Pamela Toh,Naghum Alfulaij,Marla J. Berry,Daniel J. Torres
标识
DOI:10.1016/j.freeradbiomed.2022.07.021
摘要
Fifty years have passed since the discovery of the first selenoprotein by Rotruck and colleagues. In that time, the essential nature of selenium has come to light including the dependence of the brain on selenium to function properly. Animal models have shown that a lack of certain selenoproteins in the brain is detrimental for neuronal health, sometimes leading to neurodegeneration. There is also potential for selenoprotein-mediated redox balance to impact neuronal activity, including neurotransmission. Important insights on these topics have been gained over the past several years. This review briefly summarizes the known roles of specific selenoproteins in the brain while highlighting recent advancements regarding selenoproteins in neuronal function. Hypothetical models of selenoprotein function and emerging topics in the field are also provided.
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