自愈水凝胶
弯月面
生物相容性
再生(生物学)
骨关节炎
材料科学
软骨
生物医学工程
关节软骨
膝关节
纳米技术
医学
外科
解剖
病理
细胞生物学
生物
高分子化学
物理
光学
冶金
替代医学
入射(几何)
作者
Pan Jin,Lei Liu,Xichi Chen,Lin Cheng,Weining Zhang,Gang Zhong
标识
DOI:10.3389/fbioe.2022.1082499
摘要
The meniscus is a kind of fibrous cartilage structure that serves as a cushion in the knee joint to alleviate the mechanical load. It is commonly injured, but it cannot heal spontaneously. Traditional meniscectomy is not currently recommended as this treatment tends to cause osteoarthritis. Due to their good biocompatibility and versatile regulation, hydrogels are emerging biomaterials in tissue engineering. Hydrogels are excellent candidates in meniscus rehabilitation and regeneration because they are fine-tunable, easily modified, and capable of delivering exogenous drugs, cells, proteins, and cytokines. Various hydrogels have been reported to work well in meniscus-damaged animals, but few hydrogels are effective in the clinic, indicating that hydrogels possess many overlooked problems. In this review, we summarize the applications and problems of hydrogels in extrinsic substance delivery, meniscus rehabilitation, and meniscus regeneration. This study will provide theoretical guidance for new therapeutic strategies for meniscus repair.
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