光动力疗法
自体荧光
化学发光
近红外光谱
化学
发光测量
转移
生物标志物
荧光
癌症
材料科学
发光
光电子学
医学
光学
色谱法
生物化学
物理
有机化学
内科学
作者
Jingsheng Huang,Chi Zhang,Xinzhu Wang,Xin Wei,Kanyi Pu
标识
DOI:10.1002/anie.202303982
摘要
There is growing interest in the development of chemiluminescence (CL) probes for phototheranostics because of their minimized tissue autofluorescence. However, due to a lack of near-infrared (NIR)-absorbing chemiluminophores, current probes for NIR CL-guided phototherapy are based on nanoparticles made up of multiple components. We report bright unimolecular chemiluminophores with NIR absorptions and emissions, long CL half-lives and ideal photodynamic efficiency. One luminophore is modified into an activatable probe, DBPOL , with a turn-on CL signal and photodynamic activity that are specific to a cancer biomarker. The highly sensitive DBPOL allows CL-guided photodynamic therapy which completely inhibits tumor growth and lung metastasis in mouse models, and can be applied for noninvasive monitoring of lung metastasis. We provide molecular guidelines for NIR-absorbing CL probes for imaging-guided phototherapy.
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