生物
蛋白质组学
质谱法
计算生物学
定量蛋白质组学
细胞生物学
细胞命运测定
细胞
单细胞分析
蛋白质表达
生物化学
转录因子
基因
色谱法
化学
出处
期刊:Development
[The Company of Biologists]
日期:2023-06-30
卷期号:150 (13)
被引量:2
摘要
Many developmental processes are regulated post-transcriptionally. Such post-transcriptional regulatory mechanisms can now be analyzed by robust single-cell mass spectrometry methods that allow accurate quantification of proteins and their modification in single cells. These methods can enable quantitative exploration of protein synthesis and degradation mechanisms that contribute to developmental cell fate specification. Furthermore, they may support functional analysis of protein conformations and activities in single cells, and thus link protein functions to developmental processes. This Spotlight provides an accessible introduction to single-cell mass spectrometry methods and suggests initial biological questions that are ripe for investigation.
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