Intravascular lithotripsy in heavily calcified chronic total occlusion: procedural and one‐year clinical outcomes

Abstract Background Calcification within chronic total occlusions (CTO) is strongly associated with worse outcomes. Despite the excellent success and safety of intravascular lithotripsy (IVL) in heavily calcified lesions, evidence in CTO remains scarce. Aim This study aimed to evaluate the procedural and long‐term clinical outcomes of IVL in heavily calcified CTO. Methods Patients who underwent IVL between 2019 and 2024 from an ongoing prospective multicenter registry were eligible for inclusion. Patients were therefore classified in CTO and non‐CTO groups. The efficacy and safety endpoints of CTO percutaneous coronary interventions were defined according to the CTO‐ARC consensus. In‐hospital major adverse cardiovascular events (MACE) included cardiac death, nonfatal myocardial infarction and target lesion revascularization (TVR). Results A total of 404 patients underwent IVL, of which the treated lesion was a CTO in 33 (8.2%). The mean J‐CTO score was 2.3 ± 1.1. Device success showed no significant difference between CTO and non‐CTO groups (100% vs 98.4%; p = 0.35). Comparable technical success with residual stenosis <30% was observed in both groups (90.1% in CTO vs 89.2% in non‐CTO, p = 0.83). The incidence of MACE was similar across groups during hospital stays (CTO 6.0% vs. non‐CTO 1.9%, p = 0.12), at 30‐day (CTO 9.1% vs. non‐CTO 3.0%, p = 0.07), and at 12‐month follow‐up (CTO 9.1% vs. non‐CTO 7.3%, p = 0.70). Conclusion IVL provides high procedural success and consistent clinical outcomes in both CTO and non‐CTO cases, reinforcing its role in managing heavily calcified coronary lesions.