生长分化因子
兴奋剂
GDF15型
受体
神经营养因子
内分泌学
安慰剂
内科学
转化生长因子
生物
医学
遗传学
基因
病理
骨形态发生蛋白
替代医学
作者
William B. Smith,D. Le Nguyen,Timothy M. Clough,J. Paul Schofield,Mark Kagan,Jill Kompa,Yan‐Ling He,Eleftheria Maratos–Flier,Joanna Jamontt,Linh Vong,Chad D. Schwartzkopf,Joseph D. Layne,Aimee Usera,Christopher J. O’Donnell,Kurt A. Heldwein,Ryan S. Streeper,Allison B. Goldfine
标识
DOI：10.1210/clinem/dgae550
摘要
Growth Differentiation Factor 15 (GDF15), a divergent member of the TGF-β superfamily, signals via the hindbrain glial-derived neurotrophic factor receptor alpha-like and rearranged during transfection receptor co-receptor (GFRAL-RET) complex. In nonclinical species, GDF15 is a potent anorexigen leading to substantial weight loss. MBL949 is a half-life extended recombinant human GDF15 dimer.
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