Three new phenylpropanoids from Atractylodes japonica Koidz. ex kitam

Three new phenylpropanoids (1-3), together with eighteen known phenylpropanoids (4-21), were isolated from a 70% aqueous EtOH extract of the rhizomes of Atractylodes japonica Koidz. ex Kitam. Their structures were elucidated by spectroscopic techniques, including 1D, 2D NMR spectra and HR-ESI-MS. All the isolated compounds were evaluated for cytotoxicity activity by CCK-8 assay. Compounds 1, 11 and 13 exhibited moderate activities with IC50 values in the range of 34.19-48.38 μM against human cancer (BGC-823, HepG-2, HeLa) cell lines.