Shark skin-inspired PDA-coated and peptide-functionalized wrinkled chitosan/gelatin microspheres for hemostasis and infected wound healing

polydopamine (PDA) surface modification, enhancing the aggregation of activated platelets and red blood cells at the site of injury, thereby improving the hemostatic efficacy of the microspheres. Our findings further demonstrate that these chitosan/gelatin microspheres promote the healing of infected wounds, showcasing significant hemostatic, antibacterial, and anti-inflammatory properties, as well as the capacity to mitigate oxidative stress. Thus, the chitosan/gelatin microspheres developed in this study hold considerable promise for widespread application in hemostasis and the management of various infected wounds.