Derivation of clinical-grade HLA-homozygous induced pluripotent stem cell line UNIONi001-A from umbilical cord blood of a Han Chinese male neonate

The clinical-grade iPSC line UNIONi001-A is derived from HLA-homozygous (HLAh) umbilical cord blood mononuclear cells (CBMCs) of a healthy Han Chinese male neonate. Cells were reprogrammed using episomal plasmids with OCT3/4, SOX2, KLF4, c-MYC and BCL-XL. The iPSCs exhibited typical pluripotent stem cell morphology, expressed pluripotency markers, maintained a normal karyotype, and could differentiate into three germ layers, making them suitable for cell therapy research and clinical use.