化学
磁共振成像
葡萄糖氧化酶
沸石咪唑盐骨架
生物化学
生物传感器
放射科
医学
有机化学
吸附
金属有机骨架
作者
Shiyuan Liu,Chuyao Chen,Huiting Chen,Cong Huang,Qingfan Ren,Mingyan Sun,Jia Tao,Bei Lin,Peng Zhao
标识
DOI:10.1021/acs.analchem.2c03765
摘要
Brain glucose is an important biomarker of Alzheimer’s disease (AD) and has a high specificity especially for early AD. Activatable magnetic resonance imaging (MRI) contrast agents (CAs) serve as a robust technology in the early diagnosis of many diseases; however, there is a lack of glucose-specific MRI CAs. To address this issue, in this work, we synthesized a novel MRI CA (ZIF-8/GOx@MnO2@PEG, ZGMP) that consists of porous zeolitic imidazolate framework-8 (ZIF-8) attached with glucose oxidase (GOx) and modified by MnO2 and PEG. The cascade reaction of brain glucose with ZGMP could result in the production of Mn(II) and an enhanced MRI signal. An early AD mouse model was constructed through injection of the Aβ42 oligomer into the parenchyma of mice and utilized to verify the brain glucose activated MRI of ZGMP. The results indicated a higher glucose uptake in early AD mice compared to that in normal mice, with an obviously enhanced T1WI at the region of interest. This work gets rid of the need for a specific scanning sequence for glucose MRI, paving a convenient way for MRI diagnosis of early AD.
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