Air pollution, EGFR mutation, and cancer initiation

Swanton et al.¹ find that PM_2.5 exposure is associated with EGFR/KRAS-driven lung cancer incidence. PM_2.5 increases EGFR pre-mutated alveolar type II cell progenitor function and tumorigenic activity through interstitial macrophage-secreted IL-1β, providing potential prevention approaches to inhibit cancer initiation.