Coronary CTA-based vascular radiomics predicts atherosclerosis development proximal to LAD myocardial bridging

心肌桥 心脏病学 桥接(联网) 内科学 医学 冠状动脉粥样硬化 无线电技术 冠状动脉造影 放射科 冠状动脉疾病 心肌梗塞 计算机科学 计算机网络
作者
Yan Chun Chen,Zheng Jin,Fan Zhou,Xin Wei Tao,Qian Chen,Yun Feng,Yun Su,Yu Zhang,Tongyuan Liu,Chang Sheng Zhou,Chun Xiang Tang,Jonathan Weir‐McCall,Zhongzhao Teng,Long Jiang Zhang
出处
期刊:European Journal of Echocardiography [Oxford University Press]
卷期号:25 (10): 1462-1471 被引量:4
标识
DOI:10.1093/ehjci/jeae135
摘要

Abstract Aims Cardiac cycle morphological changes can accelerate plaque growth proximal to myocardial bridging (MB) in the left anterior descending artery (LAD). To assess coronary computed tomography angiography (CCTA)-based vascular radiomics for predicting proximal plaque development in LAD MB. Methods and results Patients with repeated CCTA scans showing LAD MB without proximal plaque in index CCTA were included from Jinling Hospital as a development set. They were divided into training and internal testing in an 8:2 ratio. Patients from four other tertiary hospitals were set as external validation set. The endpoint was proximal plaque development of LAD MB in follow-up CCTA. Four vascular radiomics models were built: MB centreline (MB CL), proximal MB CL (pMB CL), MB cross-section (MB CS), and proximal MB CS (pMB CS), whose performances were evaluated using area under the receiver operating characteristic curve (AUC), integrated discrimination improvement (IDI), and net reclassification improvement (NRI). In total, 295 patients were included in the development (n = 192; median age, 54 ± 11 years; 137 men) and external validation sets (n = 103; median age, 57 ± 9 years; 57 men). The pMB CS vascular radiomics model exhibited higher AUCs in training, internal test, and external sets (AUC = 0.78, 0.75, 0.75) than the clinical and anatomical model (all P < 0.05). Integration of the pMB CS vascular radiomics model significantly raised the AUC of the clinical and anatomical model from 0.56 to 0.75 (P = 0.002), along with enhanced NRI [0.76 (0.37–1.14), P < 0.001] and IDI [0.17 (0.07–0.26), P < 0.001] in the external validation set. Conclusion The CCTA-based pMB CS vascular radiomics model can predict plaque development in LAD MB.
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