青光眼
神经保护
视网膜神经节细胞
美金刚
医学
神经科学
疾病
视神经病变
神经节
药理学
视神经
眼科
病理
生物
痴呆
作者
Jia-Hua Fang,Fei Jiang,Jingbo Li,Yanhua Zhu
出处
期刊:PubMed
日期:2012-02-05
卷期号:7 (4): 313-8
被引量:1
标识
DOI:10.3969/j.issn.1673-5374.2012.04.013
摘要
Glaucoma, the leading cause globally of irreversible blindness, is a neurodegenerative disease characterized by progressive retinal ganglion cell death. To date, no drug has been shown to prevent the retinal ganglion cell loss associated with glaucoma. Multiple mechanisms lead to ganglion cell death in glaucoma, suggesting that a neuroprotectant that has a single mode of action, like memantine, would have a limited positive effect at slowing down ganglion cell death. Conversely, simultaneously targeting several factors may be the best therapeutic approach to improve outcomes. Multifunctional drugs are fast gaining acceptance as a strategy for the treatment of complex disorders of the central nervous system, such as Parkinson's disease, Alzheimer's disease and other progressive neurodegenerative diseases. In this paper, we review the current literature on multifunctional drugs and propose a rationale for the use of multifunctional drugs in glaucomatous optic neuropathy.
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