昼夜节律
生物
生物钟
脂类学
内分泌学
脂质代谢
内科学
人口
时间生物学
生物信息学
医学
环境卫生
作者
Eric Chern‐Pin Chua,Guanghou Shui,Ivan Tian‐Guang Lee,Pauline Lau,Lik Chern Melvin Tan,Sing Chen Yeo,Buu Duyen Lam,Sarada Bulchand,Scott A. Summers,K Puvanendran,Steve Rozen,Markus R. Wenk,Joshua J. Gooley
标识
DOI:10.1073/pnas.1222647110
摘要
The circadian system regulates daily rhythms in lipid metabolism and adipose tissue function. Although disruption of circadian clock function is associated with negative cardiometabolic end points, very little is known about interindividual variation in circadian-regulated metabolic pathways. Here, we used targeted lipidomics-based approaches to profile the time course of 263 lipids in blood plasma in 20 healthy individuals. Over a span of 28 h, blood was collected every 4 h and plasma lipids were analyzed by HPLC/MS. Across subjects, about 13% of lipid metabolites showed circadian variation. Rhythmicity spanned all metabolite classes examined, suggesting widespread circadian control of lipid-mediated energy storage, transport, and signaling. Intersubject agreement for lipids identified as rhythmic was only about 20%, however, and the timing of lipid rhythms ranged up to 12 h apart between individuals. Healthy subjects therefore showed substantial variation in the timing and strength of rhythms across different lipid species. Strong interindividual differences were also observed for rhythms of blood glucose and insulin, but not cortisol. Using consensus clustering with iterative feature selection, subjects clustered into different groups based on strength of rhythmicity for a subset of triglycerides and phosphatidylcholines, suggesting that there are different circadian metabolic phenotypes in the general population. These results have potential implications for lipid metabolism disorders linked to circadian clock disruption.
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