精神科
自闭症
精神病
双相情感障碍
精神分裂症(面向对象编程)
随机对照试验
医学
萧条(经济学)
人口
安慰剂
临床心理学
心理学
儿科
内科学
锂(药物)
替代医学
经济
病理
宏观经济学
环境卫生
作者
Edward Clayton,Tanya L. Hanstock,Manohar L. Garg,Philip Hazell
出处
期刊:Acta Neuropsychiatrica
[Cambridge University Press]
日期:2007-04-01
卷期号:19 (2): 92-103
被引量:40
标识
DOI:10.1111/j.1601-5215.2007.00189.x
摘要
Objective: Long chain omega-3 polyunsaturated fatty acids (LCn-3PUFA) are in increasing use in the general population to treat health problems. The objective of the current article is to review the evidence for the rationale and benefit of LCn-3PUFA in the treatment of common psychiatric disorders in children and adolescents. Methods: A search of Psychlit, PubMed and Cochrane Databases was conducted using the terms child, adolescent, bipolar, depression, psychosis, first-episode psychosis, schizophrenia, attention deficit hyperactivity disorder (ADHD), autism, psychiatric, omega-3, n-3, docosahexaenoic acid and eicosapentaenoic acid. Further studies were identified from the bibliographies of published reviews. Results: One small randomized controlled trial with LCn-3PUFA supplementation in depression in children found a small beneficial effect over placebo. Four placebo-controlled trials showed uncertain benefit of LCn-3PUFA for ADHD. Single placebo-controlled trials showed no benefit in autism or bipolar disorder. There is an absence of studies examining benefit for first-episode psychosis or schizophrenia in children and adolescents. Conclusions: While children and adolescents are receiving LCn-3PUFA for a range of psychiatric indications, there is only evidence of likely benefit for unipolar depression.
科研通智能强力驱动
Strongly Powered by AbleSci AI