生物
效应器
记忆T细胞
CD8型
T细胞
白细胞介素21
细胞毒性T细胞
细胞生物学
免疫学
分子生物学
免疫系统
体外
遗传学
作者
Heather D. Marshall,Anmol Chandele,Yong Chae Jung,Hailong Meng,Amanda C. Poholek,Ian A. Parish,Rachel L. Rutishauser,Weiguo Cui,Steven H. Kleinstein,Joe Craft,Susan M. Kaech
出处
期刊:Immunity
[Elsevier]
日期:2011-10-28
卷期号:35 (4): 633-646
被引量:244
标识
DOI:10.1016/j.immuni.2011.08.016
摘要
CD4(+) T cells differentiate into multiple effector types, but it is unclear how they form memory T cells during infection in vivo. Profiling virus-specific CD4(+) T cells revealed that effector cells with T helper 1 (Th1) or T follicular helper (Tfh) cell characteristics differentiated into memory cells, although expression of Tfh cell markers declined over time. In contrast to virus-specific effector CD8(+) T cells, increased IL-7R expression was not a reliable marker of CD4(+) memory precursor cells. However, decreased Ly6C and T-bet (Tbx21) expression distinguished a subset of Th1 cells that displayed greater longevity and proliferative responses to secondary infection. Moreover, the gene expression profile of Ly6C(lo)T-bet(int) Th1 effector cells was virtually identical to mature memory CD4(+) T cells, indicating early maturation of memory CD4(+) T cell features in this subset during acute viral infection. This study provides a framework for memory CD4(+) T cell development after acute viral infection.
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