低温保存
氧化应激
男科
精子
细胞生物学
氧化损伤
生物
氧化磷酸化
生物信息学
胚胎
医学
生物化学
作者
Carla Tatone,Giovanna Di Emidio,Maria Elena Vento,Rosanna Ciriminna,Paolo Giovanni Artini
标识
DOI:10.3109/09513591003686395
摘要
In spite of the optimisation of cryopreservation protocols, post-thawing trauma to mammalian gametes cannot be completely avoided. Based on recent literature, cellular cryodamage in reproductive cells has been extensively characterised in terms of changes in the cell structure, whereas biochemical alterations have been poorly investigated. The present paper reviews the current knowledge about the involvement of oxidative stress in frozen-thawed cells by considering the most relevant studies in sperm and oocytes. Recognising that spermatozoa are highly susceptible to oxidative damage induced by cryopreservation, the need for further research is highlighted in order to understand whether changes in the redox state have a role in the reduced developmental potential of cryopreserved human reproductive cells.
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