化学
合成子
炔烃
过氧化物
分子内力
丙酸盐
立体专一性
烷基化
有机过氧化物
组合化学
有机化学
立体化学
催化作用
共聚物
聚合物
作者
Chunping Xu,Chris Schwartz,Joseph M. Raible,Patrick H. Dussault
出处
期刊:Tetrahedron
[Elsevier]
日期:2009-11-01
卷期号:65 (47): 9680-9685
被引量:25
标识
DOI:10.1016/j.tet.2009.09.068
摘要
The stereospecific intramolecular alkylation of a hydroperoxyacetal provides the basis for the first asymmetric synthesis of the dioxane propionate core of the peroxyplakorates. Chemoselective hydrometallation of an alkyne in the presence of a peroxide is used to introduce a synthon for the polyunsaturated side chains of the peroxyplakorates. The route suggests a general solution for the 1,2-dioxane unit in many peroxide natural products.
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