微气泡
纳米颗粒
生物医学中的光声成像
材料科学
超声波
纳米技术
光学
放射科
医学
物理
作者
Elizabeth Huynh,Benjamin Leung,Brandon Helfield,Mojdeh Shakiba,Julie-Anne Gandier,Jiang Cheng,Emma R. Master,Brian C. Wilson,David E. Goertz,Gang Zheng
标识
DOI:10.1038/nnano.2015.25
摘要
Converting nanoparticles or monomeric compounds into larger supramolecular structures by endogenous or external stimuli is increasingly popular because these materials are useful for imaging and treating diseases. However, conversion of microstructures to nanostructures is less common. Here, we show the conversion of microbubbles to nanoparticles using low-frequency ultrasound. The microbubble consists of a bacteriochlorophyll-lipid shell around a perfluoropropane gas. The encapsulated gas provides ultrasound imaging contrast and the porphyrins in the shell confer photoacoustic and fluorescent properties. On exposure to ultrasound, the microbubbles burst and form smaller nanoparticles that possess the same optical properties as the original microbubble. We show that this conversion is possible in tumour-bearing mice and could be validated using photoacoustic imaging. With this conversion, our microbubble can potentially be used to bypass the enhanced permeability and retention effect when delivering drugs to tumours.
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