雌激素受体
雌激素
内分泌学
内科学
受体
雄激素受体
生物
雌激素受体
肾
雄激素
雌激素受体α
睾丸女性化
激素
医学
前列腺癌
癌症
乳腺癌
作者
Linda I. Siegel,Thomas D. Fox
出处
期刊:Life Sciences
[Elsevier]
日期:1985-12-01
卷期号:37 (23): 2151-2156
被引量:1
标识
DOI:10.1016/0024-3205(85)90565-x
摘要
Recent research has raised the interesting possibility that the neurological mutant mouse, wobbler (wr/wr, possesses an estrogen receptor deficit analogous to the androgen receptor deficiency found in androgen-resistant mice with testicular feminization. In the present report we examined estrogen-binding activity in cytosolic extracts of kidney, liver, and brain from wobbler mice, littermate control animals, and C57BL/6J mice, using DNA-cellulose chromatography. Estrogen binding components exhibiting properties of estrogen receptors were present in all tissues examined. Estrogen receptors adhered to DNA, displayed characteristics elution profiles from DNA-cellulose, and showed high affinity and limited capacity for estradiol, in contrast to non-receptor entities which bind estradiol. The qualitative elution patterns for estrogen receptors did not differ among groups within each tissue studied, and were similar to those reported previously in mouse kidney and brain. While estrogen receptors have been shown in mouse liver by other techniques, this is the first demonstration of putative estrogen receptors in mouse liver by DNA-cellulose chromatography. No consistent deficits in estrogen receptor concentration were found in wobblers compared to littermates. Thus, the data do not support the hypothesis that the wobbler mouse is an estrogen receptor-deficient mutant.
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