In Brief Purpose: To analyze the effect of optical parameters on the outcomes of accommodating intraocular lens (IOL) implantation in cataract surgery. Setting: Department of Ophthalmology, KULeuven University, Leuven, Belgium. Methods: Thin-lens approximation optics were used to obtain a formula containing the following variables: axial length (AL), mean keratometry (Km), anterior chamber depth (ACD), and presumed anterior shift of the IOL (d(ACD)). The influence of these variables was separately analyzed. Results: The accommodative amplitude (AA) decreased with a longer AL and higher Km. The AA varied between –5.4 diopters (D) and 0.0 D in eyes with an AL between 20.0 mm and 28.0 mm and a Km between 38.0 D and 52.00 D. The d(ACD) was also a significant factor influencing the AA. The ACD had less influence on the AA. Conclusion: The obtained formula could guide selection of candidates for accommodating IOL implantation. A thin-lens approximation formula was used to analyze the influence of optical parameters (keratometry, AL, ACD, and lens shift) on the outcomes of implantation of a single-piece accommodating IOL. Results suggest satisfying accommodation is obtained only in hyperopic patients.