Iron‐Catalyzed Sonogashira Reactions

With an iron will: Terminal alkynes undergo reaction with aryl and heteroaryl iodides in the presence of an iron catalyst formed from FeCl3 and N,N′-dimethylethylenediamine (dmeda, see scheme). The method displays a broad substrate scope and is economical, environmentally friendly, and experimentally simple. A “one-pot” Sonogashira/intramolecular hydroalkoxylation has also been achieved by this method. Supporting information for this article is available on the WWW under http://www.wiley-vch.de/contents/jc_2002/2008/z801539_s.pdf or from the author. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.