细胞毒性
酮
赫拉
侧链
化学
立体化学
结构-活动关系
细胞培养
生物活性
组合化学
生物化学
细胞
体外
生物
有机化学
遗传学
聚合物
作者
Boonsong Kongkathip,Anuch Hasakunpaisarn,Suthinee Boonananwong,Ngampong Kongkathip
出处
期刊:Steroids
[Elsevier]
日期:2010-12-01
被引量:12
标识
DOI:10.1016/j.steroids.2010.05.003
摘要
In an effort to determine the pharmaceutical utility and the structural requirements for activity against tumor cell lines, 30 novel 9,11-secosterol analogues with different side chains and degrees of oxidation at C-9 were synthesized starting from hecogenin. Evaluation of the synthesized compounds for cytotoxicity against KB, HeLa and MCF-7 cell lines revealed that some important structural features are required for activity. The presence of a cholesterol-type side chain, which appears to play a major role in determining the biological activity, the existence of a ketone functional at C-9 is also crucial for anticancer activity whereas hydroxyl/ketone function at C-22 on the side chain did not increase cytotoxicity.
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