化学
海绵
一氧化氮
立体化学
珊瑚
抑制性突触后电位
细胞毒性
脂多糖
IC50型
生物化学
体外
有机化学
内分泌学
生物
植物
生态学
作者
Jia-Bao Sun,Li-Li Hong,Ru‐Yi Shang,Hongyan Liu,Lu Zhang,Liyun Liu,Lu Zhao,Wei Zhang,Fan Sun,Hou‐Wen Lin,Hou‐Wen Lin
标识
DOI:10.1016/j.bioorg.2021.104791
摘要
Dysiscalarones A-E (1-5), five new scalarane-type bishomoscalarane sesterterpenoids, were isolated from marine sponge Dysidea granulosa collected from the South China Sea, together with two known ones, honulactone A (6) and phyllofolactone I (7). The new structures were determined by extensive spectroscopic analysis including HR-ESI-MS and 1D and 2D NMR data, and their absolute configurations were assigned by single crystal X-ray diffraction analyses. The inhibitory activity of all the seven isolates on the production of nitric oxide (NO) stimulated by lipopolysaccharide (LPS) in mouse RAW 264.7 macrophages was evaluated. Of these metabolites, dysiscalarones A-B (1-2), honulactone A (6), and phyllofolactone I (7) showed inhibitory activities with respective IC50 values of 16.4, 18.5, 2.6, and 3.7 μM, which suggested that the γ-methylated α,β-unsaturated γ-lactone might be the functional group. In addition, all the seven metabolites showed no significant cytotoxicity against lung cancer PC9 cell line at the concentration of 20 μM.
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