病理
埃默林
染色质
核酸
核心
生物
核蛋白
医学
细胞生物学
遗传学
基因
转录因子
出处
期刊:Romanian Journal of Morphology and Embryology
日期:2008-01-01
卷期号:49 (4): 435-439
被引量:6
摘要
Shape and size of the nucleus, coupled with changes in chromatin amount and distribution, still remain the basic microscopic criteria for cytological diagnoses. Diagnostic recognition of the nuclear shape in pathological histology and cytology has been always based on the assumption that it is the content in nucleic acids, which determines the nuclear shape. The present review challenges this opinion, focuses on the structure, and functions of the nuclear envelope and on how these features can be exploited in diagnostic pathology. In particular, we will present the contribution of thee-dimensional modeling to the understanding of nuclear irregularities in breast cancer and papillary thyroid carcinomas. Specifically, it will be shown how tagging the nuclear membrane with anti-Emerin antibodies can represent an additional and valuable tool in the differential diagnosis of thyroid lesions. Finally, the prognostic importance of detecting irregularities of the nuclear shape in breast carcinomas by immunofluorescence staining for nuclear proteins will be discussed.
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