软骨发生
软骨
胚胎干细胞
骨关节炎
再生(生物学)
干细胞
细胞生物学
转录组
生物
细胞
生物信息学
神经科学
解剖
基因
基因表达
医学
病理
遗传学
替代医学
作者
G. Kulzhanova,Victoria L. Hansen,H. Shammas,John M. Reuter,Chia‐Lung Wu
标识
DOI:10.1016/j.joca.2022.02.054
摘要
Purpose: Cartilage has a poor self-healing capacity. Thus, it is highly challenging to treat the cartilage-associated diseases such as osteoarthritis. In this regard, tissue engineering and stem cell therapy may offer valuable means to facilitate cartilage regeneration. Nevertheless, it is challenging to induce chondrogenesis of stem cells without off-target differentiation, largely due to complicated signaling pathways, gene regulatory networks, and cell-cell interactions involved in this process.
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