化学
废止
戒指(化学)
四级碳
催化作用
药物化学
立体化学
有机化学
组合化学
对映选择合成
作者
Zhen-Hua Wang,Ping Yang,Yanping Zhang,Yong You,Jian‐Qiang Zhao,Ming‐Qiang Zhou,Wei‐Cheng Yuan
标识
DOI:10.1002/ejoc.202200110
摘要
Abstract A Cu(I)‐catalyzed ring‐opening (3+2) annulation of cyclopropenones with ketoxime acetates has been developed. In disclosed protocol, ketoxime acetates are selected as C−N splicing unit to participate in the transformation process, furnishing a sequence of highly functional 1,2‐dihydro‐pyrrol‐3‐one derivatives in good isolated yields. Besides, scale‐up reaction is conducted to demonstrate the practicability of developed methodology and a tentative mechanism for (3+2) annulation is also proposed.
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