支持向量机
稳健性(进化)
载脂蛋白E
无症状的
磁共振成像
人工智能
认知障碍
认知
神经影像学
疾病
认知功能衰退
医学
机器学习
计算机科学
心理学
模式识别(心理学)
痴呆
病理
神经科学
放射科
生物
基因
生物化学
作者
Hua Lin,Jiehui Jiang,Zhuoyuan Li,Can Sheng,Wenying Du,Xiayu Li,Ying Han
出处
期刊:Cerebral Cortex
[Oxford University Press]
日期:2022-02-10
卷期号:33 (3): 557-566
被引量:17
标识
DOI:10.1093/cercor/bhac084
摘要
Abstract Subjective cognitive decline (SCD) is a preclinical asymptomatic stage of Alzheimer’s disease (AD). Accurate diagnosis of SCD represents the greatest challenge for current clinical practice. The multimodal magnetic resonance imaging (MRI) features of 7 brain networks and 90 regions of interests from Chinese and ANDI cohorts were calculated. Machine learning (ML) methods based on support vector machine (SVM) were used to classify SCD plus and normal control. To assure the robustness of ML model, above analyses were repeated in amyloid β (Aβ) and apolipoprotein E (APOE) ɛ4 subgroups. We found that the accuracy of the proposed multimodal SVM method achieved 79.49% and 83.13%, respectively, in Chinese and ANDI cohorts for the diagnosis of the SCD plus individuals. Furthermore, adding Aβ pathology and ApoE ɛ4 genotype information can further improve the accuracy to 85.36% and 82.52%. More importantly, the classification model exhibited the robustness in the crossracial cohorts and different subgroups, which outperforms any single and 2 modalities. The study indicates that multimodal MRI imaging combining with ML classification method yields excellent and powerful performances at categorizing SCD due to AD, suggesting potential for clinical utility.
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