A tumor microenvironment-responsive Co/ZIF-8/ICG/Pt nanoplatform for chemodynamic and enhanced photodynamic antitumor therapy

Hypoxia and the overexpression of hydrogen peroxide (H2O2) in the tumor microenvironment (TME) are conducive to cancer cell proliferation, which greatly hinders cancer treatment. Here, we design a novel TME-responsive therapeutic nanoplatform Co/ZIF-8/ICG/Pt (CZIP) to achieve chemodynamic therapy (CDT) and enhanced photodynamic therapy (PDT). In this nanoplatform, under near-infrared light (NIR) irradiation, the photosensitizer indocyanine green (ICG) can generate singlet oxygen (1O2) for cancer cell apoptosis. Meanwhile, overexpressed H2O2 in the TME could be catalyzed to generate O2 by the loaded Pt to relieve tumor hypoxia and promote the PDT-induced 1O2 production. In addition, the doped Co2+ could react with H2O2 to produce hydroxyl radicals (˙OH) for CDT. The multifunctional nanoplatform CZIP showed high biosafety and a good antitumor effect, which would provide a new route for cancer therapy.